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Product Name
Human UBE2C/UBCH10 (His tag) recombinant protein
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Description
Ubiquitin-Conjugating Enzyme E2 C (UBE2C) is a 179 amino acid enzyme that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2C is highly expressed in tumor tissues and at low levels in most adult normal tissues. UBE2C is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C accepts Ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), which has E3 ubiquitin ligase activity, and targets for destruction substrates from the preceding mitosis (Cyclin A, Cyclin B, Securin, Geminin).
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Protein name
ubiquitin conjugating enzyme E2 C(UBE2C)
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Protein short names
UBCH10
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Uniprot ID
O00762
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human UBE2C/UBCH10 Met1-Pro179 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human UBE2C/UBCH10 (His tag) recombinant protein
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