Human TSC22D3 Recombinant protein (GST tag)

Human TSC22D3 Recombinant protein (GST tag)

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Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). {, PubMed:15031210}.

TSC22 domain family protein 3

DSIPI; GILZ

Q99576

TSC22D3; DSIPI; GILZ

E. coli

43-134 aa encoded by NM_001015881 was inserted into PGEX-4T vector

Human

Not tested.