Human TRIP13 Recombinant protein (GST tag)

Human TRIP13 Recombinant protein (GST tag)

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Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).

Pachytene checkpoint protein 2 homolog

PCH2

Q15645

TRIP13; PCH2

E. coli

A DNA sequence encoding the human TRIP13 (NP_001159732.1) 1-289 aa was fused with the N-terminal GST tag

Human

Not tested.