Human TPSAB1/TPS1/TPS2/TPSB1 (His tag) recombinant protein

Human TPSAB1/TPS1/TPS2/TPSB1 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates. It may play a role in innate immunity.

tryptase alpha/beta 1(TPSAB1)

TPS1; TPS2; TPSB1

Q15661

Human Cells

A DNA sequence encoding the Human TPSAB1/TPS1/TPS2/TPSB1 Ile31-Pro275 is expressed with a 6His tag at the C-terminus.

Human

>90% as determined by SDS-PAGE.