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Product Name
Human TNFRSF10C/DCR1/LIT (Fc & His tag) recombinant protein
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Description
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
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Protein name
TNF receptor superfamily member 10c(TNFRSF10C)
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Protein short names
DCR1; LIT; TRAILR3; TRID; UNQ321; PRO366
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Uniprot ID
O14798
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human TNFRSF10C/DCR1/LIT Ala26-Ala221 is expressed with a Fc, 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human TNFRSF10C/DCR1/LIT (Fc & His tag) recombinant protein
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