Human TMEM173 Recombinant protein (His tag)

Human TMEM173 Recombinant protein (His tag)

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Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). {PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:21074459, PubMed:21947006, PubMed:23027953, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:26229117, PubMed:26300263}.

Stimulator of interferon genes protein

ERIS; MITA; STING

Q86WV6

TMEM173; ERIS; MITA; STING

E. coli

A DNA sequence encoding the human TMEM173 (NP_938023.1) 174-379 aa was fused with the polyhistidine tag

Human

Not tested.