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Product Name
Human THEM4 Recombinant protein (GST tag)
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Description
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {PubMed:11598301, PubMed:17615157, PubMed:19168129, PubMed:19421406, PubMed:19453107, PubMed:22871024}.
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Protein name
Acyl-coenzyme A thioesterase THEM4
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Protein short names
CTMP
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Uniprot ID
Q5T1C6
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Gene Name
THEM4; CTMP
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human THEM4 (NP_444283.2) 1-240 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human THEM4(Full length) SDS-PAGE
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