Human TCEB2 Recombinant protein (GST tag)

Human TCEB2 Recombinant protein (GST tag)

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SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).; The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Transcription elongation factor B polypeptide 2

B8ZZU8

TCEB2

E. coli

A DNA sequence encoding the human TCEB2 (NP_996896.1) 1-117 aa was fused with the N-terminal GST tag

Human

Not tested.