Human SUMO1/SMT3C/SMT3H3/UBL1 (His tag) recombinant protein

Human SUMO1/SMT3C/SMT3H3/UBL1 (His tag) recombinant protein

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Small Ubiquitin-Related Modifier 1 (SUMO1) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO1 functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 is not active until the last four amino acids of the carboxy-terminus are cleaved off. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins and may also regulate a network of genes involved in palate development.

small ubiquitin-like modifier 1(SUMO1)

SMT3C; SMT3H3; UBL1; OK; SW-cl.43

P63165

E. coli

A DNA sequence encoding the Human SUMO1/SMT3C/SMT3H3/UBL1 Met1-Val101 is expressed with a 6His tag at the N-terminus.

Human

>95% as determined by SDS-PAGE.