Human STUB1/CHIP/PP1131 recombinant protein

Cat.#: 518718

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Product Information

  • Product Name
    Human STUB1/CHIP/PP1131 recombinant protein
  • Documents
  • Description
    E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
  • Protein name
    STIP1 homology and U-box containing protein 1(STUB1)
  • Protein short names
    CHIP; PP1131
  • Uniprot ID
    Q9UNE7
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human STUB1/CHIP/PP1131 Met1-Tyr303 is expressed.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human STUB1/CHIP/PP1131 recombinant protein

    Human STUB1/CHIP/PP1131 recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"