Human SPOP Recombinant protein (His tag)

Human SPOP Recombinant protein (His tag)

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Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. {PubMed:14528312, PubMed:15897469, PubMed:16524876, PubMed:19818708, PubMed:22085717, PubMed:22632832}.

Speckle-type POZ protein

O43791

SPOP

E. coli

A DNA sequence encoding the human SPOP (NP_001357661.1) 1-374 aa was fused with the polyhistidine tag

Human

Not tested.