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Product Name
Human SOST/UNQ2976/PRO7455/PRO7476 (His tag) recombinant protein
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Description
Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST is asecreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. SOST is produced by the osteocyte and has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
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Protein name
sclerostin(SOST)
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Protein short names
UNQ2976; PRO7455; PRO7476
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Uniprot ID
Q9BQB4
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human SOST/UNQ2976/PRO7455/PRO7476 Gln24-Tyr213 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human SOST/UNQ2976/PRO7455/PRO7476 (His tag) recombinant protein
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