Human SNX9 Recombinant protein (His tag)

Human SNX9 Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {PubMed:11799118, PubMed:12952949, PubMed:15703209, PubMed:17609109, PubMed:17948057, PubMed:18388313, PubMed:20427313, PubMed:21048941, PubMed:22718350}.

Sorting nexin-9

SH3PX1; SH3PXD3A

Q9Y5X1

SNX9; SH3PX1; SH3PXD3A

E. coli

A DNA sequence encoding the human SNX9 (NP_057308.1) 1-362 aa was fused with the polyhistidine tag

Human

Not tested.