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Product Name
Human SMPDL3A/ASML3A (His tag) recombinant protein
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Description
Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.
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Protein name
sphingomyelin phosphodiesterase acid like 3A(SMPDL3A)
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Protein short names
ASML3A
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Uniprot ID
Q92484
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human SMPDL3A/ASML3A Leu23-Tyr453 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human SMPDL3A/ASML3A (His tag) recombinant protein
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