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Product Name
Mouse ASM3A / SMPDL3A (His Tag) recombinant protein
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Description
SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR α and LXRβ function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses.
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Protein name
Acid sphingomyelinase-like phosphodiesterase 3a
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Protein short names
ASM-LIKE PHOSPHODIESTERASE 3A; AI529588; ASML3; 0610010C24RIK; ACID SPHINGOMYELINASE-LIKE PHOSPHODIESTERASE 3A; ASML3A; ACID-LIKE 3A; ASM3A; SMPDL3A; YR36GH4.1; SPHINGOMYELIN PHOSPHODIESTERASE
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Uniprot ID
P70158
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Gene Name
Smpdl3a; Asml3a
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Smpdl3a (NP_065586.3) (Met1-Leu445) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Smpdl3a consists 434 amino acids and predicts a molecular mass of 49.1 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Mouse ASM3A / SMPDL3A Protein (His Tag)
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