Human SMARCD3 Recombinant protein (GST tag)

Human SMARCD3 Recombinant protein (GST tag)

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Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {, PubMed:8804307}.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

BAF60C

Q6STE5

SMARCD3; BAF60C

E. coli

A DNA sequence encoding the human SMARCD3 (XP_054214835.1) 1-88 aa was fused with the N-terminal GST tag

Human

Not tested.