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Product Name
Human SMAD1/BSP1/MADH1/MADR1 (GST tag) recombinant protein
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Description
SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.
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Protein name
SMAD family member 1(SMAD1)
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Protein short names
BSP1; MADH1; MADR1
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Uniprot ID
Q15797
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human SMAD1/BSP1/MADH1/MADR1 Met1-Ser465 is expressed with a GST tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human SMAD1/BSP1/MADH1/MADR1 (GST tag) recombinant protein
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