Human SLAMF7/CS1/UNQ576/PRO1138 (His tag) recombinant protein

Human SLAMF7/CS1/UNQ576/PRO1138 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

SLAM family member 7(SLAMF7)

CS1; UNQ576; PRO1138

Q9NQ25

Human Cells

A DNA sequence encoding the Human SLAMF7/CS1/UNQ576/PRO1138 Ser23-Ser225 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.