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Product Name
Human SIT1/SIT (His tag) recombinant protein
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Description
Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1) is a single-pass type I membrane protein and specifically expressed in T- and B-cells. SIT1 interacts with PTPN11/SHP2, GRB2 and CSK, when it is phosphorylated. SIT1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cell. In addition, SIT1 is involved in positive selection of T-cells.
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Protein name
signaling threshold regulating transmembrane adaptor 1(SIT1)
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Protein short names
SIT
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Uniprot ID
Q9Y3P8
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human SIT1/SIT Gln65-Ser196 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human SIT1/SIT (His tag) recombinant protein
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