Human SIRT5 Recombinant protein (His tag)

Human SIRT5 Recombinant protein (His tag)

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NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. {UniProtKB:Q8K2C6, PubMed:18680753, PubMed:21908771, PubMed:22076378, PubMed:24140062, PubMed:24703693}.

NAD-dependent protein deacylase sirtuin-5, mitochondrial

SIR2L5

Q9NXA8

SIRT5; SIR2L5

E. coli

A DNA sequence encoding the human SIRT5 (NP_001363733.1) 1-310 aa was fused with the polyhistidine tag

Human

Not tested.