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Product Name
Human SIKE1 Recombinant protein (His tag)
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Description
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {PubMed:16281057}.
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Protein name
Suppressor of IKBKE 1
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Protein short names
SIKE
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Uniprot ID
Q9BRV8
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Gene Name
SIKE1; SIKE
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SIKE1 (NP_001095866.1) 112-211 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human SIKE1 SDS-PAGE
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