Human SHARPIN Recombinant protein (His tag)

Human SHARPIN Recombinant protein (His tag)

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Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. {PubMed:21455173, PubMed:21455180, PubMed:21455181}.

Sharpin

SIPL1

Q9H0F6

SHARPIN; SIPL1; PSEC0216

E. coli

A DNA sequence encoding the human SHARPIN (XP_016869377.1) 1-326 aa was fused with the polyhistidine tag

Human

Not tested.