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Product Name
Human S100A7/PSOR1/S100A7C recombinant protein
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Description
S100A7 is a 11-12 kDa member of the S100 family of EF hand calcium binding proteins. Human S100A7 shares 32% amino acid sequence identity with mouse S100A7A, the closest related protein in mouse. It is acetylated at the N-terminus and binds both calcium and zinc ions. S100A7 is up-regulated in keratinocytes of psoriasis and atopic dermatitis lesions, as well as in epithelial cells of the tongue, eye, and female genital tract. Its up-regulation can be induced by bacterial exposure, inflammatory cytokines, or epidermal barrier disruption. S100A7 supports epithelial integrity through killing E. coli by sequestration of zinc and through inducing the up-regulation of tight junction proteins. The interaction of S100A7 with RAGE promotes the migration of immune cells and the infiltration of macrophages into tumor sites.
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Protein name
S100 calcium binding protein A7(S100A7)
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Protein short names
PSOR1; S100A7C
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Uniprot ID
P31151
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human S100A7/PSOR1/S100A7C Met1-Gln101 is expressed.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human S100A7/PSOR1/S100A7C recombinant protein
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