Human RWDD3 Recombinant protein (His tag)

Human RWDD3 Recombinant protein (His tag)

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• Material Safety Data Sheets (MSDS)

Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination. {PubMed:17956732, PubMed:22009797, PubMed:23469069, PubMed:23508108}.

RWD domain-containing protein 3

RSUME

Q9Y3V2

RWDD3; RSUME

E. coli

A DNA sequence encoding the human RWDD3 (NP_001265176.2) 1-185 aa was fused with the polyhistidine tag

Human

Not tested.