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Product Name
Human RSPO3/PWTSR/THSD2 (Fc & His tag) recombinant protein
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Description
R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases, and one TSP type-1 domain, RSPO3 founctions as a activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Otherwise, RSPO3 may negatively regulate the TGF-beta pathway.
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Protein name
R-spondin 3(RSPO3)
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Protein short names
PWTSR; THSD2
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Uniprot ID
Q9BXY4
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human RSPO3/PWTSR/THSD2 Gln22-His272 is expressed with a Fc, 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human RSPO3/PWTSR/THSD2 (Fc & His tag) recombinant protein
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