Human RNF41 Recombinant protein (His tag)

Human RNF41 Recombinant protein (His tag)

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Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). {, UniProtKB:Q8BH75, PubMed:12411582, PubMed:14765125, PubMed:15632191, PubMed:17210635, PubMed:18541373, PubMed:19483718, PubMed:24949970}.

E3 ubiquitin-protein ligase NRDP1

FLRF; NRDP1

Q9H4P4

RNF41; FLRF; NRDP1; SBBI03

E. coli

A DNA sequence encoding the human RNF41 (NP_005776.1) 1-317 aa was fused with the polyhistidine tag

Human

Not tested.