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Product Name
Human RABIN8 Recombinant protein (His tag)
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Description
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. {PubMed:12221131, PubMed:20890297, PubMed:20937701}.
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Protein name
Rab-3A-interacting protein
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Protein short names
RABIN8
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Uniprot ID
Q96QF0
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Gene Name
RAB3IP; RABIN8
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RAB3IP (XP_006719289.3) 277-510 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human RABIN8 SDS-PAGE
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