Human PUM2 Recombinant protein (His tag)

Human PUM2 Recombinant protein (His tag)

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Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. {PubMed:18776931, PubMed:21397187, PubMed:22345517, PubMed:22955276, PubMed:25340845, PubMed:25349211}.

Pumilio homolog 2

KIAA0235; PUMH2

Q8TB72

PUM2; KIAA0235; PUMH2

E. coli

A DNA sequence encoding the human PUM2 (XP_047299760.1) 717-1066 aa was fused with the polyhistidine tag

Human

Not tested.