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Product Name
Human PTPN14 Recombinant protein (His tag)
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Description
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {PubMed:10934049, PubMed:12808048, PubMed:17893246, PubMed:20826270, PubMed:22233626, PubMed:22525271, PubMed:22948661}.
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Protein name
Tyrosine-protein phosphatase non-receptor type 14
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Protein short names
PEZ; PTPD2
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Uniprot ID
Q15678
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Gene Name
PTPN14; PEZ; PTPD2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PTPN14 (NP_005392.2) 1-351 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human PTPN14 SDS-PAGE
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