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Product Name
Human PPP4R2 Recombinant protein (His tag)
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Description
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {PubMed:10769191, PubMed:12668731, PubMed:18614045, PubMed:20154705}.
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Protein name
Serine/threonine-protein phosphatase 4 regulatory subunit 2
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Uniprot ID
Q9NY27
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Gene Name
PPP4R2; SBBI57
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PPP4R2 (NP_001304954.1) 1-205 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human PPP4R2 SDS-PAGE
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