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Product Name
Human PLDN Recombinant protein (GST tag)
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Description
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. {PubMed:17182842, PubMed:21998198}.
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Protein name
Biogenesis of lysosome-related organelles complex 1 subunit 6
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Protein short names
PA; PLDN
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Uniprot ID
Q9UL45
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Gene Name
BLOC1S6; PA; PLDN
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human BLOC1S6 (NP_036520.1) 1-172 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human PLDN(Full length) SDS-PAGE
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