Human PI4K2B Recombinant protein (His tag)

Human PI4K2B Recombinant protein (His tag)

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Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {PubMed:11923287}.

Phosphatidylinositol 4-kinase type 2-beta

Q8TCG2

PI4K2B

E. coli

A DNA sequence encoding the human PI4K2B (NP_060793.2) 132-481 aa was fused with the polyhistidine tag

Human

Not tested.