Human PF4/CXCL4/SCYB4 recombinant protein

Human PF4/CXCL4/SCYB4 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.

platelet factor 4(PF4)

CXCL4; SCYB4

P02776

E. coli

A DNA sequence encoding the Human PF4/CXCL4/SCYB4 Glu32-Ser101 is expressed.

Human

>95% as determined by SDS-PAGE.