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Human CXCL4 / PF4 recombinant protein

Cat.#: 502165

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Product Information

  • Product Name
    Human CXCL4 / PF4 recombinant protein
  • Documents
  • Description
    Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
  • Protein name
    Platelet factor 4
  • Protein short names
    PF4; PF-4; MGC138298; SCYB4; CXCL4
  • Uniprot ID
    P02776
  • Gene Name
    PF4; CXCL4; SCYB4
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CXCL4 (NP_002610.1) (Glu 32-Ser 101) was expressed.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CXCL4 comprises 71 amino acids with a predicted molecular mass of 7.8 kDa as estimated in SDS-PAGE under reducing conditions.
  • Purity
    > 80 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to inhibit human bFGF / FGF2 dependent proliferation of Balb/c3T3 mouse fibroblasts. The ED50 for this effect is typically 5-40 μg/ml.
    2. Measured by its binding ability in a functional ELISA. Immobilized human CXCL4 at 20 μg/ml (100 μl/well) can bind biotinylated human VEGF165. The EC50 of biotinylated human VEGF165 is 9.97 μg/ml.
  • Validations

    Human CXCL4 / PF4 Protein SDS-PAGE

    Human CXCL4 / PF4 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"