Human PDZK1 Recombinant protein (His tag)

Human PDZK1 Recombinant protein (His tag)

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A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).

Na(+/H(+ exchange regulatory cofactor NHE-RF3

CAP70; NHERF3; PDZD1

Q5T2W1

PDZK1; CAP70; NHERF3; PDZD1

E. coli

A DNA sequence encoding the human PDZK1 (XP_054192969.1) 21-320 aa was fused with the polyhistidine tag

Human

Not tested.