Human PDCD6 Recombinant protein (GST tag)

Human PDCD6 Recombinant protein (GST tag)

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Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. {, PubMed:16132846, PubMed:17889823, PubMed:19520058, PubMed:19864416, PubMed:21893193}.

Programmed cell death protein 6

ALG2

O75340

PDCD6; ALG2

E. coli

A DNA sequence encoding the human PDCD6 (NP_037364.1) 1-191 aa was fused with the N-terminal GST tag

Human

Not tested.