Human OMGP (aa 1-420, His Tag) recombinant protein

Human OMGP (aa 1-420, His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.

Oligodendrocyte-myelin glycoprotein

OMGP; OMG

P23515

OMG; OMGP

Human Cells

A DNA sequence encoding the mature form of human OMGP (P23515-1) (Met 1-Asn 420) without the pro peptide was expressed, fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human OMGP comprises 407 amino acids and has a predicted molecular mass of 46 kDa. The apparent molecular mass of rh OMGP is approximately 120-130 kDa in SDS-PAGE under reducing conditions due to high glycosylation.

> 97 % as determined by SDS-PAGE

Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. Human OMG immobilized at 0.8 μg/ml, 100 μl/well will mediate >20% C6 cell adhesion.