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Product Name
Human NR2F6 Recombinant protein (His tag)
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Description
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {PubMed:10644740, PubMed:10713182, PubMed:11682620, PubMed:18701084}.
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Protein name
Nuclear receptor subfamily 2 group F member 6
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Protein short names
EAR2; ERBAL2
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Uniprot ID
F1D8R3
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Gene Name
NR2F6; EAR2; ERBAL2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human NR2F6 (NP_005225.2) 1-404 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human NR2F6(Full length) SDS-PAGE
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