Human NOS2 Recombinant protein (His tag)

Human NOS2 Recombinant protein (His tag)

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Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). {UniProtKB:P29477, PubMed:19688109, PubMed:25417112, PubMed:7531687, PubMed:7544004}.

Nitric oxide synthase, inducible

NOS2A

P35228

NOS2; NOS2A

E. coli

A DNA sequence encoding the human NOS2 (NP_000616.3) 240-480 aa was fused with the polyhistidine tag

Human

Not tested.