Human NFE2 Recombinant protein (GST tag)

Human NFE2 Recombinant protein (GST tag)

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Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {PubMed:11154691, PubMed:16287851}.

Transcription factor NF-E2 45 kDa subunit

Q16621

NFE2

E. coli

A DNA sequence encoding the human NFE2 (NP_001387294.1) 1-373 aa was fused with the N-terminal GST tag

Human

Not tested.