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Product Name
Human NFASC / Neurofascin (Fc Tag) recombinant protein
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Description
NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
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Protein name
Neurofascin
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Protein short names
NEUROFASCIN HOMOLOG; AA387016; NFASC; MKIAA0756; D430023G06RIK; NEUROFASCIN; NF; RP11-494K3.1; NRCAML
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Uniprot ID
O94856
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Gene Name
NFASC; KIAA0756
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human NFASC (NP_001005388.2) (Met1-Gln939) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human NFASC consists 1156 amino acids and predicts a molecular mass of 130 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human NFASC / Neurofascin protein (Fc Tag)
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