Human NCR3?CD337? (His & Fc Tag) recombinant protein

Human NCR3?CD337? (His & Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity, and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.

Natural cytotoxicity triggering receptor 3

CD337; NKP30; NCR3; 1C7; MALS; LST1; LY117; DAAP-90L16.3

O14931

NCR3; 1C7; LY117

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Gly 135) of human NCR3 (NP_667341.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Human

The recombinant human NCR3/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 365 amino acids and has a predicted molecular mass of 41 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NCR3/Fc monomer is approximately 50-55 kDa due to glycosylation.

> 97 % as determined by SDS-PAGE