Human NCR3/1C7/LY117 (Fc tag) recombinant protein

Human NCR3/1C7/LY117 (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.

natural cytotoxicity triggering receptor 3(NCR3)

1C7; LY117

O14931

Human Cells

A DNA sequence encoding the Human NCR3/1C7/LY117 Leu19-Thr138 is expressed with a Fc tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.