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Product Name
Human NCK1/NCK (His tag) recombinant protein
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Description
Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing signals from receptor tyrosine kinases to downstream signal recipients, such as ELK1-dependent transcriptional activation in response to activated Ras signaling.
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Protein name
NCK adaptor protein 1(NCK1)
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Protein short names
NCK
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Uniprot ID
P16333
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human NCK1/NCK Met1-Ser377 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human NCK1/NCK (His tag) recombinant protein
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