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Product Name
Human/Mouse/Rat FNDC5/FRCP2 (His tag) recombinant protein
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Description
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.
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Protein name
fibronectin type III domain containing 5(FNDC5)
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Protein short names
FRCP2
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Uniprot ID
Q8NAU1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human/Mouse/Rat FNDC5/FRCP2 Asp32-Glu143 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human/Mouse/Rat
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human/Mouse/Rat FNDC5/FRCP2 (His tag) recombinant protein
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