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Product Name
Human MICAL1 Recombinant protein (GST tag)
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Description
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. {PubMed:18305261, PubMed:21864500, }.
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Protein name
Protein-methionine sulfoxide oxidase MICAL1
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Protein short names
MICAL; NICAL
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Uniprot ID
Q8TDZ2
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Gene Name
MICAL1; MICAL; NICAL
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human MICAL1 (NP_001273542.1) 737-1086 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human MICAL1 SDS-PAGE
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