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Product Name
Human MAGED1 Recombinant protein (GST tag)
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Description
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {PubMed:20864041}.
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Protein name
Melanoma-associated antigen D1
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Protein short names
NRAGE
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Uniprot ID
Q9Y5V3
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Gene Name
MAGED1; NRAGE; PP2250; PRO2292
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human MAGED1 (NP_001005333.1) 1-346 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human MAGED1 SDS-PAGE
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