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Product Name
Human LYPD3/C4.4A/UNQ491/PRO1007 (His tag) recombinant protein
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Description
Ly6/PLAUR domain containing3 (LYPD-3) is a GPI-linked protein. The structure of LYPD-3 is similar to the urokinasetype plasminogen activator receptor (uPAR). LYPD-3 is a 6 -100 kDa molecule with variable cell type-specific N-O-linked glycosylation, mature human LYPD-3 contains two uPAR/Ly6 domains and a Ser/Thr/Pro-rich (STP) region includes a protease sensitive site . The interaction of LYPD-3 with Laminin 1 and 5 on neighboring cells promotes the adhesion, spreading, and migration of tumor cells. LYPD-3 additionally interacts with Galectin-3 and the anterior gradient proteins AG-2 and AG-3. LYPD-3 overexpression in non-small cell lung cancer is predictive of increased mortality.
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Protein name
LY6/PLAUR domain containing 3(LYPD3)
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Protein short names
C4.4A; UNQ491; PRO1007
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Uniprot ID
O95274
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human LYPD3/C4.4A/UNQ491/PRO1007 Leu31-His286 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human LYPD3/C4.4A/UNQ491/PRO1007 (His tag) recombinant protein
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