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Product Name
Human LIN7C Recombinant protein (His tag)
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Description
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
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Protein name
Protein lin-7 homolog C
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Protein short names
MALS3; VELI3
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Uniprot ID
Q9NUP9
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Gene Name
LIN7C; MALS3; VELI3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human LIN7C (NP_060832.1) 1-197 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human LIN7C(Full length) SDS-PAGE
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