Human LCP2 (His tag) recombinant protein

Human LCP2 (His tag) recombinant protein

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Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

lymphocyte cytosolic protein 2(LCP2)

Q13094

E.coli

A DNA sequence encoding the Human LCP2 Met1-Pro533 is expressed with a T7 tag at the N-terminus, 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.